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Vardenafil Tablets
Valif

  • Vardenafil Tablets
  • ED046
  • In Stock

Premium High Quality Product & Original Active Substance!

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   Manufacturer's Suggested Retail Price (MSRP) per pill is $7.62 ! Buying from us will save you at least 37.93%

Package per pill Price SAVINGS BONUS Order
20mg * 10 pills
$4.73 $47.30 $0.00
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SILVER BONUS
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20mg * 20 pills
$3.41 $68.20 $26.40
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SILVER BONUS
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20mg * 30 pills
$2.61 $78.30 $63.60
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20mg * 40 pills
$2.21 $88.40 $100.80
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20mg * 50 pills
$1.96 $98.00 $138.50
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20mg * 60 pills
$1.76 $105.60 $178.20
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20mg * 70 pills
$1.68 $117.60 $213.50
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20mg * 80 pills
$1.61 $128.80 $249.60
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20mg * 90 pills
$1.52 $136.80 $288.90
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20mg * 120 pills
$1.28 $153.60 $414.00
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20mg * 150 pills
$1.18 $177.00 $532.50
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20mg * 180 pills
$1.12 $201.60 $649.80
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SILVER BONUS
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Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum.

Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs)

Zhewitra is based on Vardenafil, which increases blood flow to the pelvic organs (besides having other positive effects). It is this dose of active substance Vardenafil that is optimal for the vast majority of men. In men, it causes an excellent erection at the right time, and the girls – the possibility of deep sensations and prolonged orgasms (dosage for women – strictly no more than a quarter of the tablet). You can take them only once a day. The interval between receptions should not be less than 24 hours. The action of Zhewitra lasts 6-8 hours.

Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum.

This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum.

This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.

Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle.

This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. M1 shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil.

Absorption: Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.

Route of elimination: After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose).

Half life: 4-5 hours

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Vardenafil.

Tell your doctor or pharmacist if you have any medical conditions.

Common side effects may include: flushing (warmth, redness, or tingly feeling)stuffy nose, sinus painheadache, dizzinessupset stomach or back pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Noel
25/Jul/2024

I am a 60 year old male and began noticing erectile dysfunction problems when I turned 59 last year. I had been using Viagra for the past several months. I was browsing the website's (RxMedWorld) pages and went to my account to refill my Viagra order but noticed i had a free pack of Zhewitra as a bonus from last week's campaigns you guys had, anyways, so I refilled and received that one too. Wow. The next night I used it and wow...like a rock! Zhewitra works very well, better than Viagra! Zhewitra makes my penis very hard and happy, so my lady is very happy too! And without any noticeable side effects.

Ross
23/Dec/2023

As a 72 year old had a problem maintaining a decent erection throughout sex. I have used Viagra and Cialis 20mg without total success but after the bonus Zhewitra 20 mg pack was received, magic happened! I am thrilled at the improvement. Sex is back to stay.

Nik
22/Dec/2023

35 male, athletic in great shape. Have dealt with minor to serious erectile dysfunction for a few years now. Thought it was time for me to find a solution so i asked friend who knew a friend, you know, finally landed here, bought Zhewitra 20mg and boy am I glad i did. What a night! Never in my life even in my teens have I had so much fun in the bedroom! Took 1 x 20mg pill after a hot shower and a couple beers. Straight to couch to "watch a movie".

Robert
09/Mar/2023

Have been experiencing mild Erectile Dysfunction for several years now, but never been a major problem until recently... Mainly because of a high stress level with work and some other things. Ordered 20 mg Zhewitra. I didn't feel like I needed the whole 20 mg, so I cut it in half. I took it about an hour before bedtime, and just a few minutes later I could feel it kick in. We went 2 rounds last night, and I could have gone a few more, and I'm still feeling it working this morning... The only side effects was some stuffiness but nothing too bad, and a mild headache that went away with some aspirin.

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